Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial.
نویسنده
چکیده
ImPRECISION: Limitations to Interpretation of a Large Randomized Clinical Trial Garret A. FitzGerald MD, FRS The Institute for Translational Medicine and Therapeutics, Perelman School of Medicine University of Pennsylvania, Philadelphia Address for correspondence: Dr. FitzGerald Institute for Translational Medicine and Therapeutics 10‐123 Smilow Center for Translational Research 3400 Civic Center Boulevard, Building 421 Philadelphia, PA 19104‐5158 Tel: 215‐573‐0900 | Fax: 215‐573‐9135 Email: [email protected]
منابع مشابه
Impact of adding a limitations section to abstracts of systematic reviews on readers’ interpretation: a randomized controlled trial
BACKGROUND To allow an accurate evaluation of abstracts of systematic reviews, the PRISMA Statement recommends that the limitations of the evidence (e.g., risk of bias, publication bias, inconsistency, imprecision) should be described in the abstract. We aimed to evaluate the impact of adding such limitations sections on reader's interpretation. METHOD We performed a two-arm parallel group ra...
متن کاملTrial and error. How to avoid commonly encountered limitations of published clinical trials.
The randomized controlled clinical trial is the gold standard scientific method for the evaluation of diagnostic and treatment interventions. Such trials are cited frequently as the authoritative foundation for evidence-based management policies. Nevertheless, they have a number of limitations that challenge the interpretation of the results. The strength of evidence is often judged by conventi...
متن کاملTHE EFFECT OF EIGHT WEEKS OF SCAPULAR FOCUSED TRAINING ON PAIN, ELECTRICAL ACTIVITY OF SELECTED SHOULDER MUSCLES, AND UPPER EXTREMITY PERFORMANCE IN MALE VOLLEYBALL PLAYERS WITH SHOULDER IMPINGEMENT SYNDROME: A RANDOMIZED CLINICAL TRIAL
Background & Aims: Impingement syndrome is the most common injury and cause of movement limitations and pain in the shoulder area. The purpose of this study was to investigate the effect of eight weeks of focused scapular training on pain, electrical activity of shoulder muscles, and upper extremity performance in male volleyball players with shoulder impingement syndrome. Materials & Methods:...
متن کاملEstimating the Power of Indirect Comparisons: A Simulation Study
BACKGROUND Indirect comparisons are becoming increasingly popular for evaluating medical treatments that have not been compared head-to-head in randomized clinical trials (RCTs). While indirect methods have grown in popularity and acceptance, little is known about the fragility of confidence interval estimations and hypothesis testing relying on this method. METHODS We present the findings of...
متن کاملEvaluation of the Effect of Nebulized N-Acetylcysteine on Respiratory Secretions in Mechanically Ventilated Patients: Randomized Clinical Trial
Background: The purpose of our study was to evaluate an inexpensive and available method to reduce mucous impactions in mechanically ventilated patients.Methods: This randomized clinical trial was conducted on 40 mechanically ventilated patients aged 15-90 years. The patients were randomly allocated into two arms; 20 cases and 20 controls. The cases received N-acetylcysteine via their nebulizer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Circulation
دوره 135 2 شماره
صفحات -
تاریخ انتشار 2017